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Re: st: How to handle large (or small) odds ratios

From   David Hoaglin <>
Subject   Re: st: How to handle large (or small) odds ratios
Date   Fri, 18 May 2012 08:16:38 -0400

Hi, Tim.

Thanks for the update.

When a category contains a small number of observations, it is often
necessary to combine it with other categories.



On Fri, May 18, 2012 at 7:53 AM, Tim Evans <> wrote:
> Hi David,
> Thanks for your response - my table formatting was not quite like that when it was sent!
> Having reviewed the data behind the analysis, Ive decided the prudent approach is to remove the staging analysis for those particular adjusted O/Rs as they were based on small numbers. I've also had a look at:
> 'How should one interpret 1.00E+00 as the LCI and UCI for Complex mixed
> and stromal?  Is the standard error of that OR so small that the LCI
> and UCI both round to 1.00?  Many other CIs are fairly wide.'
> Again, having looked at the number of cases, they are based upon either a single case, or a very small fraction of the total and appear to be behaving in the exact manner as the reference group. Given the apparent lack of robustness here, I've removed these also.
> Thanks for helping me to see the obvious. The results I have now are much more sensible.
> Best wishes
> Tim

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