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Re: st: pk analysis suite: elementary questions about -pkequiv-, -pkcross-, and -pkshape-

From   Michael McCulloch <>
Subject   Re: st: pk analysis suite: elementary questions about -pkequiv-, -pkcross-, and -pkshape-
Date   Sun, 21 Feb 2010 16:54:54 -0800

Thank you Joseph, I've ordered a copy of Stephen Senn's text, and wasn't dismayed by the title of Pippa M. Simpson's poster. Looks like both will be useful learning tools, and I appreciate your having recommended them.

On Feb 20, 2010, at 8:27 PM, Joseph Coveney wrote:

Michael McCulloch wrote:

Thank you kindly for the very helpful response and example.
You write "the potential for carryover effects (by whatever name) to
confound crossover studies
is often more serious with outcomes other than chemical
concentrations." Might you be able to recommend some reading (either
published or online tutorials) on this issue in crossover studies?


Outside of the biopharmaceutics-specific literature, the following reference
would be a good place to start:

Stephen J. Senn, _Cross-over Trials in Clinical Research_ Second Edition.
Chichester: John Wiley & Sons, 2002.

Online, there is a paper delivered at a SAS meeting some years ago:

Its title comes across as a bit too negative, but the paper does touch on some
of the pitfalls in design and execution of a crossover study.

Joseph Coveney

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Best wishes,

Michael McCulloch
Pine Street Foundation
124 Pine Street
San Anselmo, CA 94960-2674
tel:	415-407-1357
fax: 	206-338-2391

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