st: RE: Combining Harard Ratios using METAN

[Joe Canner <jcanner1@jhmi.edu>]

Claire,

Although it is not well documented, you can do meta-analysis of hazard ratios in -metan- as you would with odds ratios or relative risks, but since HRs are not explicitly allowed you need to log-transform the HR and 95% CI first and then use the -eform- option:

gen ln_HR=ln(HR)
gen ln_LL=ln(LL)
gen ln_UL=ln(UL)

metan ln_HR ln_LL ln_UL, eform effect("HR") null(1) ....

As always, you will also have to decide whether to use a fixed effects or random effects model.

Regards,
Joe Canner
Johns Hopkins University School of Medicine

-----Original Message-----
From: owner-statalist@hsphsun2.harvard.edu [mailto:owner-statalist@hsphsun2.harvard.edu] On Behalf Of Claire Rushton
Sent: Wednesday, March 26, 2014 8:57 AM
To: statalist@hsphsun2.harvard.edu
Subject: st: Combining Harard Ratios using METAN

I will soon be performing a meta analysis of a number of studies reporting
HR and their confidence intervals. I cannot find the command in METAN help.
Could anyone help me with this please?

Thank you,
Claire
-- 
Claire A Rushton
Lecturer in Nursing and NIHR Doctoral Research Fellow
Health Services Research Unit
Innovation Centre 1
Keele University
Staffordshire
ST5 5NB
Telephone: 01782 733768
Email: c.a.rushton@keele.ac.uk
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