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Re: st: Extrapolated inferences and confidence intervals

From   Maarten buis <>
Subject   Re: st: Extrapolated inferences and confidence intervals
Date   Wed, 24 Jun 2009 15:26:54 +0000 (GMT)

--- On Wed, 24/6/09, Fred Wolfe wrote:
> I wonder if anyone on the Stata list
> may be able to suggest a method
> to solve this problem using Stata.
> I am trying do determine the 
> prevalence and confidence intervals 
> of a side effect to a treatment.
> Several thousand treated subjects
> have taken a drug. They are asked if
> they had a specific side effect to the
> drug. Those that say no are classified
> as being side effect negative. Those
> that say yes are contacted to obtain
> the name of their physician, and the
> physician is asked to verify the side
> effect. Only about one third of
> physicians can be contacted, and from
> them we can get the proportion positive
> and negative for the side effect. Assume
> that the non-responses are unrelated to
> the outcome. I can extrapolate from the
> responding physicians to the non-responding
> physicians and calculate an overall
> prevalence of the side effect. What I
> would like to do is to obtain confidence
> intervals for this prevalence estimate,
> but I do not see an easy way to do this in
> Stata. I wonder if anyone might suggest a
> solution.

Sounds like a problem for Multiple Imputation, 
though 2/3 missing may be pushing it a bit. 
This is implemented in Stata as -ice-, type
in Stata -findit ice-, to findit and to find 
several papers on it in the Stata Journal.

-- Maarten

Maarten L. Buis
Institut fuer Soziologie
Universitaet Tuebingen
Wilhelmstrasse 36
72074 Tuebingen


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