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st: Multiple dosing levels

From   "William Parsons" <>
To   <>
Subject   st: Multiple dosing levels
Date   Thu, 27 Mar 2008 15:23:20 -0400

I used stcox to evaluate risk of outcome x  associated with ever-never exposure to y.  I am now interested in a dose-response analysis for all number of doses of y.  Sometimes subsequent doses are received in a matter of weeks, sometimes they are received years after the first dose.  Should I create separate records for each period of follow-up at a given number of doses?  If I do this, is there any reason to maintain multiple-observation per subject data? Or can the records at each number of doses be analyzed as separate subjects?  I ask this last point because it is a HUGE dataset (> 10^6).


Thanks,  Will

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