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Re: st: re Kaplan-Meier survival analysis model


From   Ziad El-Khatib <[email protected]>
To   [email protected]
Subject   Re: st: re Kaplan-Meier survival analysis model
Date   Wed, 23 Jan 2008 03:02:48 -0800

Thank you!
well my intention is to see how the progress is over time.
to be clearer and more specific, to compare time took group of HIV
patients with resistance at baseline versus group of HIV patients
without resistance at baseline to show treatment failure.
 option 1) treatment failure due to baseline resistance
 option 2) treatment failure due to resistance development during treatment
 option 3) no treatment failure at all
 option 4) patient dropped out (maybe this can not be added here?)


Thank you and best regards
ziad




On Jan 23, 2008 2:55 AM, Maarten buis <[email protected]> wrote:
> --- Ziad El-Khatib <[email protected]> wrote:
> > My understanding to KM survival model is to have the variable related
> > to the 'survival' event to be coded as (0: as nothing happened or 1:
> > as the event did happen) For example if we are monitoring death: 1)
> > died, 0) did not die.
> >
> > I am assessing variable for sickness, to see if there is difference
> > in time to show between
> >   option 1) patients who were sick before treatment and became sicker
> > after treatment
> >
> >   option 2) patients who were not sick before treatment but became
> > sicker after treatment
> >
> >  option3) And there are patients who did not show any sickness at
> > all.
> >
> >
> > would i code them as follow:
> > option1 : code 1
> > option2: code 2
> > option3: code 0
>
> Survival models model the duration till an effent, so that does not
> seem to apply in your case. I would suppose that you are interested in
> whether or not someone became sicker after treatment, and you want to
> control for whether or not someone was already sick. I would create two
> dummies:
> sicker: 1) got sicker, 0) not sicker
> sick: 1) was sick, 0) was not sick.
>
> and than type:
> logit sicker sick
>
> Hope this helps,
> maarten
>
> -----------------------------------------
> Maarten L. Buis
> Department of Social Research Methodology
> Vrije Universiteit Amsterdam
> Boelelaan 1081
> 1081 HV Amsterdam
> The Netherlands
>
> visiting address:
> Buitenveldertselaan 3 (Metropolitan), room Z434
>
> +31 20 5986715
>
> http://home.fsw.vu.nl/m.buis/
> -----------------------------------------
>
>
>       __________________________________________________________
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>
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-- 
Ziad El-Khatib
AIDS Unit
National Institute for Communicable Diseases (NICD)
1 Modderfontein Road
Private Bag X4, Sandringham, 2131
Johannesburg, South Africa
Mobile: +27 (0) 72-52 39 716
Phone: +27 (0) 11-386 6433
Fax (NICD): +27 (0)11 386 6453
Fax (alternative): +27 (0)866 18 2871
http://www.nicd.ac.za/

Division of International Health (IHCAR)
Karolinska Institutet
www.phs.ki.se/ihcar

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