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From |
Richard Goldstein <[email protected]> |

To |
[email protected] |

Subject |
Re: st: Number Needed to be Treated (NNT) |

Date |
Fri, 03 Aug 2007 12:55:21 -0400 |

This is an interesting and, to me, new definition of Number Needed to Harm (NNH) I use NNH quite differently as one over the difference in adverse event (side effect) rates and I think it is much more useful this way (e.g., one person can both improve and have a side effect -- or just one or, of course, neither. I would prefer to see the situation that Ronan is talking about as one where neither treatment is clearly better (from just the benefit side) Rich Goldstein Ronan Conroy wrote:

On 1 Aug 2007, at 13:55, Svend Juul wrote:NNT = 15.230769 (95% CI: 5.0701399; -15.169883) - the negative numbers meaning that exposure to x may prevent low birthweight.

The negative number has the interpretation of Number Needed to Harm (with its minus sign removed), just as a negative Attributable fraction is more usually written as "Prevented fraction in the exposed/population"

Thus the confidence interval in Svend's example runs from an NNT of 5 to an NNH of 15.

The other useful statistic that I recommend is the NTN (number treated needlessly). It is the NNT-1. So if you have to treat 400 people to prevent one event, then the number treated needlessly is 399. A salutary reflection for the average doctor.

P Before printing, think about the environment

=================================

Ronan Conroy

[email protected]

Royal College of Surgeons in Ireland

120 St Stephen's Green, Dublin 2, Ireland

+353 (0)1 402 2431

+353 (0)87 799 97 95

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**References**:**Re: st: Number Needed to be Treated (NNT)***From:*"Svend Juul" <[email protected]>

**Re: st: Number Needed to be Treated (NNT)***From:*Ronan Conroy <[email protected]>

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