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Re: st: Re: assigning household characteristics to an individual with missing values


From   "Neil Shephard" <nshephard@gmail.com>
To   statalist@hsphsun2.harvard.edu
Subject   Re: st: Re: assigning household characteristics to an individual with missing values
Date   Thu, 2 Mar 2006 06:25:32 +0800

On 3/2/06, Friedrich Huebler <huebler@rocketmail.com> wrote:
> Out of curiosity, what kind of data has households in which everyone
> is either a father, mother, son, or daughter?

I've no idea if this is the case here (and strongly doubt it is), but
such data is collected under a study design called the Transmission
Disequilibrium Test (TDT), where the investigator is interested in
distortions in the ratio of alleles transmitted from the parents to
off-spring (who will in such cases be affected by some sort of
disease).

Its a test for linkage and association and was first proposed by...

Spielmen, McGinnis & Ewens (1993) Transmission test for linkage
disequilibrium: the insulin gene region and insulin-dependent diabetes
mellitus (iddm). American Journal of Human Genetics 52(3):506-516

...and has undergone a number of extensions and developments, to
account missing parents, quantitative traits, and so forth, although
for such a test whether some one is considered the 'household head' is
irrelevant.

The test has even been implemented in Stata...

. findit tdt

Neil
--
"There is always an easy solution to  every...problem - neat,
plausible, and wrong." - H. L. Mencken

Email - nshephard@gmail.com / neilshep@cyllene.uwa.edu.au
Website - http://slack.ser.man.ac.uk/
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