On 3/2/06, Friedrich Huebler <[email protected]> wrote:
> Out of curiosity, what kind of data has households in which everyone
> is either a father, mother, son, or daughter?
I've no idea if this is the case here (and strongly doubt it is), but
such data is collected under a study design called the Transmission
Disequilibrium Test (TDT), where the investigator is interested in
distortions in the ratio of alleles transmitted from the parents to
off-spring (who will in such cases be affected by some sort of
disease).
Its a test for linkage and association and was first proposed by...
Spielmen, McGinnis & Ewens (1993) Transmission test for linkage
disequilibrium: the insulin gene region and insulin-dependent diabetes
mellitus (iddm). American Journal of Human Genetics 52(3):506-516
...and has undergone a number of extensions and developments, to
account missing parents, quantitative traits, and so forth, although
for such a test whether some one is considered the 'household head' is
irrelevant.
The test has even been implemented in Stata...
. findit tdt
Neil
--
"There is always an easy solution to every...problem - neat,
plausible, and wrong." - H. L. Mencken
Email - [email protected] / [email protected]
Website - http://slack.ser.man.ac.uk/
Blog - http://slack---line.blogspot.com/
Flickr - http://www.flickr.com/photos/slackline/
*
* For searches and help try:
* http://www.stata.com/support/faqs/res/findit.html
* http://www.stata.com/support/statalist/faq
* http://www.ats.ucla.edu/stat/stata/
