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From |
Ron�n Conroy <[email protected]> |

To |
<[email protected]> |

Subject |
Re: st: Sample size calculation |

Date |
Thu, 27 Oct 2005 12:17:27 +0100 |

On 26 DF�mh 2005, at 20:34, <[email protected]> <[email protected]> wrote:

Thanks. We plan to do the experiment in humans and they will be treatedNo, no. Sample size calculations are done on the difference between the two groups expressed in standard deviations. The actual size of the SD is irrelevant.

with Rebif. The expected size of difference is 2 SD (to be clinically

significant) but my understanding is that to be able to calculate the

sample size (alpha = 0.05, beta = 0.20), we have to know estimated mean

and SD? Is this not true?

. sampsi 0 2, sd(1)

Estimated sample size for two-sample comparison of means

Test Ho: m1 = m2, where m1 is the mean in population 1

and m2 is the mean in population 2

Assumptions:

alpha = 0.0500 (two-sided)

power = 0.9000

m1 = 0

m2 = 2

sd1 = 1

sd2 = 1

n2/n1 = 1.00

Estimated required sample sizes:

n1 = 6

n2 = 6

. sampsi 0 20, sd(10)

Estimated sample size for two-sample comparison of means

Test Ho: m1 = m2, where m1 is the mean in population 1

and m2 is the mean in population 2

Assumptions:

alpha = 0.0500 (two-sided)

power = 0.9000

m1 = 0

m2 = 20

sd1 = 10

sd2 = 10

n2/n1 = 1.00

Estimated required sample sizes:

n1 = 6

n2 = 6

Two standard deviations is a lot. With a two standard deviation difference between your means,

. mwstati 2 1 1 , i

Mann-Whitney statistic for this situation is: 0.9214

The Mann-Whitney statistic is 0.92. In other words, there is a 92% chance that a person with MS taken at random will have a higher cytokyne measurement than a control taken at random. You might consider a Mann Whitney statistic of 0.75 to be more realistic as indicating a clinically important difference. This occurs with a difference of 1 standard deviation.

Ron�n Conroy

[email protected]

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**References**:**st: Sample size calculation***From:*<[email protected]>

**Re: st: Sample size calculation***From:*Neil Shephard <[email protected]>

**Re: st: Sample size calculation***From:*<[email protected]>

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