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Re: st: False negatives in clinical work

From   "Christopher W. Ryan" <>
To   <>
Subject   Re: st: False negatives in clinical work
Date   Tue, 18 Feb 2003 12:05:42 -0500

How are the cases considered positive for the disease?  Is test A or test B 
considered the "gold standard?"

At first glance, it seems to me that it would be difficult to speak of "false 
negatives" when the diagnostic test under study (A or B?) is not dichotomous.

Christopher W. Ryan, MD
SUNY Upstate Medical University Clinical Campus at Binghamton
and Wilson Family Practice Residency
40 Arch Street, Johnson City, NY  13790
Public key generated with PGP 602i available at
or via

"If you want to build a ship, don't drum up the men to gather wood, divide the 
work and give orders. Instead, teach them to yearn for the vast and endless 
sea."  [Antoine de St. Exupery]

On Tue, 18 Feb 2003 11:40:42 EST, wrote:
>I'm trying to help a pathologist friend with a study and am not sure
>how to
>proceed.  She has 15 cases that are positive for a disease.  There
>are two
>standard methods for diagnosing the disease from tissue samples, say
>A and B.
>A and B each produce a rating of High, Medium or Low on the
>indicator used
>for diagnosis.  Each case has been rated by each method.  She would
>like to
>know if there is a statistically significant difference in the
>number of
>false negatives between the two methods.  It would also be useful to
>know if
>collapsing, for example, High and Medium into one category yields a
>false negative rate.
>Any suggestions on how to proceed most welcome.
>Tom Dietz
>Professor of Sociology and Crop and Soil Sciences
>Acting Director of the Environmental Science and Policy Program
>Acting Associate Dean for Environmental Science and Policy, College
>Agriculture and Natural Resources, College of Natural Science,
>College of
>Social Science
>Michigan State University
>Off campus phone:  802-372-4389
>Off campus fax:  802-372-4389
>Office:  118 Linton
>On campus phone:  517-355-0302
>On campus fax:  517-353-3355
>*   For searches and help try:

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