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st: False negatives in clinical work

Subject   st: False negatives in clinical work
Date   Tue, 18 Feb 2003 11:40:42 EST

I'm trying to help a pathologist friend with a study and am not sure how to 
proceed.  She has 15 cases that are positive for a disease.  There are two 
standard methods for diagnosing the disease from tissue samples, say A and B. 
 A and B each produce a rating of High, Medium or Low on the indicator used 
for diagnosis.  Each case has been rated by each method.  She would like to 
know if there is a statistically significant difference in the number of 
false negatives between the two methods.  It would also be useful to know if 
collapsing, for example, High and Medium into one category yields a lower 
false negative rate.
  Any suggestions on how to proceed most welcome.
 Tom Dietz

Professor of Sociology and Crop and Soil Sciences
Acting Director of the Environmental Science and Policy Program
Acting Associate Dean for Environmental Science and Policy, College of 
Agriculture and Natural Resources, College of Natural Science, College of 
Social Science
Michigan State University
Off campus phone:  802-372-4389
Off campus fax:  802-372-4389
Office:  118 Linton
On campus phone:  517-355-0302
On campus fax:  517-353-3355
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