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Re: st: Meta-Analysis of Hazard Ratios and Confidence Intervals


From   "Roger B. Newson" <r.newson@imperial.ac.uk>
To   statalist@hsphsun2.harvard.edu
Subject   Re: st: Meta-Analysis of Hazard Ratios and Confidence Intervals
Date   Wed, 19 Sep 2012 10:08:11 +0100

Hazard ratios have weighted geometric means, which are calculated by -metan- in exactly the same way as weighted geometric means for odds ratios, with the same choice between the fixed-effect and randomly-variable effect methods.

An alternative possibility might be to do meta-analyses using the SSC packages -eclplot-, -parmhet-, and -parmest- (which has a -metaparm- module for this purpose). These offer the user the additional choice of a nonrandomly-variable-effect meta-analysis (as well as the fixed-effect and randomly-variable-effect options). However, -metan- can provide a more instant solution, if Belinda is in a hurry.

Best wishes

Roger

Roger B Newson BSc MSc DPhil
Lecturer in Medical Statistics
Respiratory Epidemiology and Public Health Group
National Heart and Lung Institute
Imperial College London
Royal Brompton Campus
Room 33, Emmanuel Kaye Building
1B Manresa Road
London SW3 6LR
UNITED KINGDOM
Tel: +44 (0)20 7352 8121 ext 3381
Fax: +44 (0)20 7351 8322
Email: r.newson@imperial.ac.uk
Web page: http://www.imperial.ac.uk/nhli/r.newson/
Departmental Web page:
http://www1.imperial.ac.uk/medicine/about/divisions/nhli/respiration/popgenetics/reph/

Opinions expressed are those of the author, not of the institution.

On 19/09/2012 05:19, Belinda Butcher wrote:
I had read this, but am unsure what to do with the confidence intervals, all the examples I have seen calculate the logodds and selogodds basically from the 2x2 table (which I don't have)?

Suggestions?

Belinda Butcher BSc(Hons) MBiostat PhD
Director - Biostatistics & Medical Writing
WriteSource Medical Pty Ltd

PO Box 1521
Lane Cove NSW 1595

M: 0418 286 014
E: bbutcher@writesourcemedical.com.au

On 19/09/2012, at 2:12 PM, JVerkuilen (Gmail) wrote:

On Tue, Sep 18, 2012 at 8:03 PM, Belinda Butcher
<bbutcher@writesourcemedical.com.au> wrote:
Hi,

I am conducting a meta-analysis of some cancer data using the hazard ratio for overall survival and the upper and lower 95% confidence intervals.

Usually meta-analyses of a ratio estimator like a hazard ratio,
relative risk or odds ratio are better conducted on the log scale.


--
JVVerkuilen, PhD
jvverkuilen@gmail.com

"Out beyond ideas of wrong-doing and right-doing there is a field.
I'll meet you there. When the soul lies down in that grass the world
is too full to talk about." ---Rumi
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