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st: Meta-Analysis of Hazard Ratios and Confidence Intervals


From   Belinda Butcher <bbutcher@writesourcemedical.com.au>
To   statalist@hsphsun2.harvard.edu
Subject   st: Meta-Analysis of Hazard Ratios and Confidence Intervals
Date   Wed, 19 Sep 2012 10:03:13 +1000

Hi,

I am conducting a meta-analysis of some cancer data using the hazard ratio for overall survival and the upper and lower 95% confidence intervals.

I am using the following command in STATA MP v11 for Mac.

--metan oshr osll osul, effect ("Hazard Ratio") fixed lcols(study author year treatment) double by(drug) null(1) --

However, in the output, I get 

Significance test(s) of ES=0

Drug Type A       z= 21.53     p = 0.000
Drug Type B             z= 25.27     p = 0.000
Drug Type C           z=  4.44     p = 0.000
Overall               z= 33.43     p = 0.000

I need to compare the ES to 1 not zero, as the relative risk =1 is the point of no difference (not 0).  I can't seem to find how to do this.

Your help is greatly appreciated.

Kind regards,

Belinda Butcher BSc(Hons) MBiostat PhD
Director - Biostatistics & Medical Writing
WriteSource Medical Pty Ltd

PO Box 1521
Lane Cove NSW 1595

M: 0418 286 014
E: bbutcher@writesourcemedical.com.au


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