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Re: msg for Statalist: "Which input for standard error in metaregression"

From   Roger Harbord <[email protected]>
To   [email protected], Maurizio La Rocca <[email protected]>
Subject   Re: msg for Statalist: "Which input for standard error in metaregression"
Date   Mon, 4 Jan 2010 09:40:38 +0000

Dear Maurizio:

On Mon, Jan 4, 2010 at 8:41 AM, Maurizio La Rocca <[email protected]> wrote:

> I have a crucial doubt about the weights to use in a meta-regression.
> For fixed-effect I have to use this Stata command: vwls Y(effect size)
> DummyX1 DummyX2. Sd(StandardErrorEffectSize)
> For fixed-effect I have to use this Stata command, using reml- residual
> maximum likelihood - as option: metareg Y(effect size) DummyX1 DummyX2,
> wsse(StandardErrorEffectSize) bsest(reml)
> My doubt concerns the weight.
> If I compute a variance-weighted least squared regression do I have to input
> in the stata command the Standard Error of the Effect Size or the inverted
> squared standard error?
> End running a metareg (random-effect), is it correct, in this case, the use
> of the Standard Error of the Effect Size?

You have the command syntax right: -vwls- and -metareg- take the
standard error as argument to the sd() and wsse() options
respectively. (Note that Stata is case-sensitive so it may object if
you type "Sd" rather than "sd".)

> Moreover, I have a second doubt.
> Please, does anybody of you know how to compute R^2 after a
> variance-weighted least squared regression? Is it possible to compute it?

The current version of -metareg- includes in the output an "adjusted
R-squared" value that is computed as the percentage reduction in the
(residual) between-study variance when covariates are fitted (compared
to the random-effects meta-analysis model with no covariates). To
install the latest version of -metareg- type "findit metareg" in Stata
and click on the link labelled "sbe23_1", which is currently the fifth
item down (at least in Stata 11 with the latest updates installed). Or
if that doesn't work for you, try "net sj 8-4 sbe23_1". For further
discussion of the updated version of -metareg- see:

Harbord RM, Higgins JPT. Meta-regression in Stata. Stata Journal 2008;
8(4):493-519. <>


Roger Harbord
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