Ricardo Ovaldia wrote:
I am still trying to figure how to do an equivalence test in Stata.
All I have is a 2x2 table (Treatment x outcome). I can use -cs- or -rdci-
to get the CI, but how do I compute the equivalence limit assuming delta=25%,
for example?
Also, can -pkequiv- be trick into doing this analysis?
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If your delta is 25% for a risk difference (difference in proportions), then you
can reject the null hypothesis of nonequivalence in favor of the alternative
hypothesis of therapeutic equivalence if the confidence interval (CI) from -cs-
(Wald) or -rdci- (various other methods) lies between -0.25 and +0.25.
For equivalence (as opposed to "noninferiority"), a 90% CI is conventionally
used. This corresponds to a two, one-sided test (TOST) method with alpha =
0.05.
So, set -level- at 90% for -cs- or -rdci- (whichever command you choose), and if
the displayed CI is between the limits that you set for equivalence (e.g., -0.25
to +0.25, in your example), then you can declare bioequivalence.
Joseph Coveney
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