Dear Moleps,
at a very first glance, this seems a job for a bayesian statistician.
A hopefully useful refeence might be: Parmigiani G. Modelling in Medical
Decision Making. A Bayesian Approach. Chichester: Wiley, 2002.
Sorry I cannot be more helpful as far as Stata codes are concerned.
Kind Regards,
Carlo
-----Messaggio originale-----
Da: [email protected]
[mailto:[email protected]] Per conto di moleps islon
Inviato: domenica 22 marzo 2009 15.37
A: [email protected]
Oggetto: st: Gene-incidence question/simulation
Dear statalisters,
I'm studying a tumor A that has a probability (x) of a being linked to
a genetic mutation (B) that also predisposes (penetrance approx 65%(y)
by 70 years) to condition Z. Now I've got 217 cases of A that resulted
in 11 cases of Z over 8534 years of followup years (among the 217
cases). I need to determine the number of patients with B given that
there is also a background incidence of 6/100000 for Z.We know that
x<<y. Besides running a simulation is there a more analytical way of
estimating x and y given my data???
Best wishes,
Moleps
*
* For searches and help try:
* http://www.stata.com/help.cgi?search
* http://www.stata.com/support/statalist/faq
* http://www.ats.ucla.edu/stat/stata/
*
* For searches and help try:
* http://www.stata.com/help.cgi?search
* http://www.stata.com/support/statalist/faq
* http://www.ats.ucla.edu/stat/stata/
