This is more of an FDA-type issue. You have the outcome variable as the
union of some variables. If you are looking for a drug approval, you
need to specify if you want to get a license (or a paper) if any of the
outcomes is 'significant' or if all must be. In the former, you are in
a multiple testing situation and must use something like a Bonferroni
adjustment, while in the latter "all" case, you can test all hypotheses
at the 0.05 level and all must be significant.
Check the International Conference on Harmonization website (ICH) and
look at E9 and E3 - good starting point
Tony
Peter A. Lachenbruch
Department of Public Health
Oregon State University
Corvallis, OR 97330
Phone: 541-737-3832
FAX: 541-737-4001
-----Original Message-----
From: [email protected]
[mailto:[email protected]] On Behalf Of Christopher
W. Ryan
Sent: Friday, January 23, 2009 10:51 AM
To: statalist
Subject: st: compound outcome variables (not specifically Stata-related)
I would like to try to do a journal club session for my family practice
residents on the uses, and especailly the pitfalls, of compound outcome
variables, like "stroke or myocardial infarction or coronary bypass
surgery." They appear frequently in clinical trial literature. Can
anyone recommend any good articles discussing the issues? Thanks.
--Chris Ryan
--
Christopher W. Ryan, MD
SUNY Upstate Medical University Clinical Campus at Binghamton
40 Arch Street, Johnson City, NY 13790
cryanatbinghamtondotedu
PGP public keys available at http://home.stny.rr.com/ryancw/
"If you want to build a ship, don't drum up the men to gather wood,
divide the work and give orders. Instead, teach them to yearn for the
vast and endless sea." [Antoine de St. Exupery]
*
* For searches and help try:
* http://www.stata.com/help.cgi?search
* http://www.stata.com/support/statalist/faq
* http://www.ats.ucla.edu/stat/stata/
*
* For searches and help try:
* http://www.stata.com/help.cgi?search
* http://www.stata.com/support/statalist/faq
* http://www.ats.ucla.edu/stat/stata/
