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st: Area under the curve

From   Peter DeGaris <>
Subject   st: Area under the curve
Date   Wed, 01 Oct 2008 20:46:25 +1000

Hi All,

I am currently using Stata 9.2 July 2007.

I have a rather unusual pharmacokinetic type data set that I need to run AUC's on. The time axis is both positive and negative and hence the two sections of the data need to be analysed separately (day -35 to day 0 and day 0 to day +35). The follow up times are not identical for patients either before or after day 0 (ie different time points for the data for different patients). Some patients have a missing value at time = 0.

I have split the data set to allow calculation of the AUC for the negative time period by making these negative times positive.

I want to fit a cubic spline to the data and then calculate the AUC for varying time periods (ie day - 10 to day 0 or day 0 to day +10). I have been trying to do this using the pkcollapse function.
Due to the irregular follow up times for different patients and some missing data at time=0, I need Stata to fit the spline and calculate the AUC under the spline for each patient for a consistent period say (day 0 to day +10) even if that particular patient has only data points at say day 0, 1, 4, 8, 12, 16 . ie day 10 data value would need to be predicted from the cubic spline to have the AUC calculated over day 0 to 10 and not the AUC from day 0 to 8. In addition I don't want Stata to insert a value of 0 at time=0 if that measurement is missing.
I hope that's a clear enough explanation???


Peter DeGaris
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