# st: RE: Re: Imposing Parameter Restriction

 From Hyeok Jeong <[email protected]> To [email protected] Subject st: RE: Re: Imposing Parameter Restriction Date Fri, 06 Aug 2004 15:17:30 -0700

```Dear Joseph and Hung-Jen,

Thank you for the kind advice, which I tried.
Basically the idea of reparametrization of Hung-Jen worked.
And the idea of converting nl to ml of Joseph will be tried also.
Thanks!

Hyeok

-----Original Message-----
From: [email protected]
[mailto:[email protected]]On Behalf Of Joseph Coveney
Sent: Thursday, August 05, 2004 6:35 PM
To: Statalist
Subject: st: Re: Imposing Parameter Restriction

Hyeok Jeong wrote:

I am trying to estimate a nonlinear model using "nl" and this is my first
time of doing it. Let's say the model is written as "y= f(l;a,b)," where a
and b are the parameters to be estimated. The model restricts the parameter
space such that "0 < a < 1" and "b <1".
Without imposing any restrictions, it turns out that estimates from "nl"
method violate these restrictions.

I am just guessing there should be some obvious ways of imposing
restrictions on parameter space, which I cannot find.
Could anyone help me on how I can put these restrictions on parameter space,
using "nl" (nonlinear least square) or using any nonlinear estimation method
in stata in general?

----------------------------------------------------------------------------
----

To my knowledge there is no simple way to impose parameter space boundaries
in
-nl- in Stata.  I ran into the same problem some years ago with using -nl-
for
pharmacokinetic parameter estimation, which have a positive parameter space.
One approach is to reparameterize the coefficient as ln(coefficient), which
assures that the estimate will lie above zero.  But there is no easy
boundary
statement in -nl- to my knowledge.

If it's any consolation, in my experience years ago with specialized
pharmacokinetics packages and with SAS's PROC NONLIN, which do allow simple
boundary statements, the badly behaving estimates often slam up against the
boundary in the first iteration or two and then sit there at the boundary
throughout the remaining iterations until "convergence," unless a fortuitous
local saddlepoint was found in the sum squares.

You might wish to consider writing an -ml- implementation of your nonlinear
regression.  It's actually not that difficult, and it provides a good
alternative to least squares.  To see how, refer to the FAQ on StataCorp's
Web
site, "How do I estimate a nonlinear model using ml?"
http://www.stata.com/support/faqs/stat/nl_ml.html .  -ml- will allow the
-constraint- option, and it might be possible to define a set of constraints
that will hold the coefficients in the parameter space.

Joseph Coveney

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```