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st: pk analysis suite: elementary questions about -pkequiv-, -pkcross-, and -pkshape-


From   Michael McCulloch <mm@pinestreetfoundation.org>
To   Statalist Statalist <statalist@hsphsun2.harvard.edu>
Subject   st: pk analysis suite: elementary questions about -pkequiv-, -pkcross-, and -pkshape-
Date   Fri, 19 Feb 2010 17:00:30 -0800

Hello Statalist friends,
I'm studying the manual (v11) for the pk suite, and have 3 questions:
1. Regarding the "carry" variable created by -pkshape-, in the manual example (p. 1325), is "carry" simply an indicator that shows whether or not a measurement was made in the same period/treatment combination, so that if
	"carry"==0, then no carryover is possible, and if
	"carry"==A, then a carryover effect is possible, but no evidence yet?

2. Can -pkcross- be used in to compare treatment response (e.g. pain score) in an AB-BA crossover study design, that was not a test of a biopharmaceutical drug concentration?

3. -pkequiv- performs bioequivalence tests using serum levels of biopharmaceutical drug concentration. Can the command also be used instead to measure *any* continuous outcome, measured following some other non-pharmaceutical intervention?


Best wishes,

Michael McCulloch
Pine Street Foundation
124 Pine Street
San Anselmo, CA 94960-2674
tel:	415-407-1357
fax: 	206-338-2391

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