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st: more cases than controls

From   Ricardo Ovaldia <[email protected]>
To   [email protected]
Subject   st: more cases than controls
Date   Mon, 22 Mar 2004 12:56:43 -0800 (PST)

Dear all,

Please pardon the non-Stata topic.

We recently submitted a manuscript for publication to
a major medical journal. It was a case-control study
with 329 cases and 126 controls. One of the reviewers
wrote that "to have such a larger number of cases was
statistically atypical" and asked if the "authors find
that the use of the same control for multiple patients
significantly limits results"?

I never heard of any biases or other problems cause by
having more cases than controls in a study. We had
sufficient power and the difference for our main
outcome was highly significant (less than 0.00001). Am
I missing something or is it that this reviewer does
not understand the case-control designed? By the way
this was not a matched study design.
Thank you,

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