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st: meta analysis/data synthesis case series when no control grp
From
"Gupta, Ajay K" <[email protected]>
To
"[email protected]" <[email protected]>
Subject
st: meta analysis/data synthesis case series when no control grp
Date
Fri, 10 May 2013 15:44:57 +0000
Dear Statalist members,
I was wondering if anyone of you could help me with this problem.
I am trying to collate and synthesis the findings of several case-series reports on a surgical intervention, where there is no control arm. I am trying to find a summary statistic for change in proportion of a comorbidity before and after the intervention. Each one of these case series (whilst having same intervention) is of a different sample size, has a different proportion of the comorbidity ( of interest) at the time of intervention, and also have a different follow-up period to report the proportion (prevalence) of the co-morbidity (post intervention). Can you please let me know the following, or provide me with your comments.
a. Can I use the usual metan commands for collating these results, replacing the risk difference with the prevalence difference?.
b. Is there a way to weight these effect sizes to incorporate not only the study size but also the pre-existing proportions of the comorbidities ( which may influence the difference), or is there any other way that is acceptable in these circumstances?.
Many thanks for your help.
Best wishes,
Ajay
[email protected]
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