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Re: st: Cox proportional hazard model

From   Michael McCulloch <>
Subject   Re: st: Cox proportional hazard model
Date   Thu, 12 Aug 2010 14:04:13 -0700

Dear Nyasha,
It seems your main outcome is time to employment, and your co-variates include:
	# of non-patient household members living together with the patient
	patient receiving AIDS medication (yes/no)

Questions which also occur to me are:
can you measure duration of AIDS medication prior to start of observation in your study? are you observing for the event (becoming employed) only for the AIDS patient or for any household member? do you have multiple observations (in which case a time-dependent model can be built)?

If the answer to that last question is yes, then a relevant paper may be: Fewell, Z., M. A. Hernan, et al. (2004). "Controlling for time- dependent confounding using marginal structural models." The Stata Journal 4(4): 402-20

Michael McCulloch

On Aug 12, 2010, at 12:32 PM, Nyasha Tirivayi wrote:


I would like to model  intrahousehold transitions from unemployment to
employment. In the household are:
1. A patient receiving AIDS medication
2. And non-patient household members living together with the patient.

I am thinking of applying the cox proportional hazard model, where
duration of AIDS medication is the time variable. How can  I analyse
the transitions by other non-patient family members, when they do not
receive AIDS medication? Do I assign the time variable to the patient
and his/her non-patient family members?

Kindly advise


Nyasha Tirivayi
Maastricht University
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Best wishes,

Michael McCulloch, LAc MPH PhD
Pine Street Foundation
124 Pine Street
San Anselmo, CA 94960-2674
tel:	415-407-1357
fax: 	206-338-2391

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