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Re: st: case-control study vs entire dataset


From   Ronan Conroy <rconroy@rcsi.ie>
To   "statalist@hsphsun2.harvard.edu" <statalist@hsphsun2.harvard.edu>
Subject   Re: st: case-control study vs entire dataset
Date   Tue, 26 May 2009 16:15:33 +0100

The reviewer is barking.

Your data are prospective: that is, the exposure to risk factors was measured and patients followed up for incidence of endpoints. It's a clinical cohort study.

Case control data is based on recruiting patients based on the occurrence or non-occurrence of an endpoint and establishing exposure to risk retrospectively.

With a cohort design, you can calculate incidence rates and ratios, as well as hazard. None of this is possible with case control designs. And the reviewer is telling you to throw away data? People have been sent to work in Montana for less...


On 25 Beal 2009, at 15:51, moleps islon wrote:

Getting feedback on a manuscript that was submitted from a
retrospective analysis of tumor characteristics and outcome the
peer-reviewer is requesting a case-control analysis. In this
manuscript we've used logistic regression and cox modelling. As far as
I understand using stocc for matching data would entail discarding
data. Is there any advantage of using a control-case instead of
multivariate regression analysis whereby other factors are controlled
for???




Ronan Conroy
=================================

rconroy@rcsi.ie
Royal College of Surgeons in Ireland
Epidemiology Department,
Beaux Lane House, Dublin 2, Ireland
+353 (0)1 402 2431
+353 (0)87 799 97 95
+353 (0)1 402 2764 (Fax - remember them?)
http://rcsi.academia.edu/RonanConroy

P    Before printing, think about the environment




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