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Re: st: RE: case-control study vs entire dataset


From   moleps islon <moleps2@gmail.com>
To   statalist@hsphsun2.harvard.edu
Subject   Re: st: RE: case-control study vs entire dataset
Date   Tue, 26 May 2009 10:41:40 +0200

Thank you for confirming what I thought. It'll be a pleasure
responding to the reviewer:-)

Regards
Moleps


On Mon, May 25, 2009 at 11:11 PM, Kieran McCaul
<Kieran.McCaul@uwa.edu.au> wrote:
> ..
>
> It's difficult to know what the reviewer means by "a case-control
> analysis" based on the information that you have provided.
>
> If the reviewer is suggesting that you match on some factors before
> doing the analysis, then this is clearly wrong.
>
> Matching is not done to control for confounding in a case-control study,
> despite what some people believe.  Matching is done for efficiency: if
> you know beforehand that a particular factor will be associated with
> both exposure and disease, then matching on this factor will give you
> more power for a given sample size.
>
> Matching is an element of the design of a study and is done when the
> data is being collected.  If you already have the data, you gain nothing
> by matching, other than possibly losing power if data ends up being
> discarded after you have matched.
>
> So, with the data already collected, multivariate analysis will allow
> you to control for other factors.
>
>
> ______________________________________________
> Kieran McCaul MPH PhD
> WA Centre for Health & Ageing (M573)
> University of Western Australia
> Level 6, Ainslie House
> 48 Murray St
> Perth 6000
> Phone: (08) 9224-2701
> Fax: (08) 9224 8009
> email: Kieran.McCaul@uwa.edu.au
> http://myprofile.cos.com/mccaul
> http://www.researcherid.com/rid/B-8751-2008
> ______________________________________________
> Man is a credulous animal, and must believe something; in the absence of
> good grounds for belief,
> he will be satisfied with bad ones. Bertrand Russell
>
> -----Original Message-----
> From: owner-statalist@hsphsun2.harvard.edu
> [mailto:owner-statalist@hsphsun2.harvard.edu] On Behalf Of moleps islon
> Sent: Monday, 25 May 2009 10:51 PM
> To: statalist@hsphsun2.harvard.edu
> Subject: st: case-control study vs entire dataset
>
> Getting feedback on a manuscript that was submitted from a
> retrospective analysis of tumor characteristics and outcome the
> peer-reviewer is requesting a case-control analysis. In this
> manuscript we've used logistic regression and cox modelling. As far as
> I understand using stocc for matching data would entail discarding
> data. Is there any advantage of using a control-case instead of
> multivariate regression analysis whereby other factors are controlled
> for???
>
> Regards,
>
> Moleps
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