.- help for ^aucdist^ .- Calculates the distribution of a series of plasma concentration curves. ------------------------------------------------------------------------ ^aucdist^ id time concentration [^if^ exp] [^in^ range] [^,^ ^f^it^(^integer^)^ ^t^rapezoid ^g^enerate(variable) ^stat^(^cmax^ | ^tmax^ | ^inf^) ^nodots^ ^gr^aph graph_options ] Description ----------- ^aucdist^ calculates the distribution of a series of plasma concentration measurements made on a series of patients. The median and first 4 moments of the distribution are reported as is the probability the distribution is normal. Optionally, you can graph the distribution. Options ------- ^fit(^#^)^ specifies the number of points from the end of the measured data to use to fit the model used to calculate the AUC from 0 to infinity. The default is to use the last 3 points. ^trapezoid^ specifies that the integral be computed using the simple trapezoidal rule -- i.e., the sum of (xvar[i] - xvar[i-1])*(yvar[i] + yvar[i-1])/2 -- rather than using cubic splines (the default). Cubic splines will give superior results for most smooth functions; for irregular functions, ^trapezoid^ may give better results. ^stat^(^cmax^ | ^tmax^ | ^inf^) specifies which statistic should be summarized. The default is the AUC, however, you can specify ^cmax^ for the maximum concentration or ^tmax^ for the time at max concentration or ^inf^ to use the log concentration from 0 to infinity. ^generate(^varname^)^ specifies to create a new variable with the AUC (C max, T max, log conc 0 -inf.). ^nodots^ supresses the dots shown during calculation. ^graph^ specifies to show the graph of the distribution of the statistic. By default, the AUC. Examples -------- . ^aucdist id time conc^ (Show measures) . ^aucdist time conc, fit(7) t^ (Use last 7 points and trapazod to fit model) . ^aucdist id time conc, generate(auc)^ (Save the AUC in a variable called AUC) . ^aucdist id time conc, stat(cmax)^ (Summarize using the C max parameter) . ^aucdist id time conc, gr normal bin(25) (Graph the dist with a normal curve superimosed with a bin size of 25)