.- help for ^auccalc^ .- Calculates the area under a plasma concentration curve --------------------------------------------------------- ^auccalc^ time concentration [^if^ exp] [^in^ range] [^,^ ^f^it^(^integer^)^ ^t^rapezoid ^line^ ^exp^ ^log^ ^g^raph graph options ] Description ----------- ^auccalc^ calculates the area under a plasma concentration curve. The program alse calculates the Cmax, time of max. conc. , half life and elimination rate. Options ------- ^fit(^#^)^ specifies the number of points from the end of the measured data to use to fit the model used to calculate the AUC from 0 to infinity. The default is to use the last 3 points. ^trapezoid^ specifies that the integral be computed using the simple trapezoidal rule -- i.e., the sum of (xvar[i] - xvar[i-1])*(yvar[i] + yvar[i-1])/2 -- rather than using cubic splines (the default). Cubic splines will give superior results for most smooth functions; for irregular functions, ^trapezoid^ may give better results. ^graph^ specifies to show the graph of the AUC. If neither the line, exp, or log option is specified the AUC from 0 to Tmax is plotted. Otherwise, the appropriate AUC from 0 to infinity is plotted. ^line^, ^exp^, ^log^ specifies which fit to show for plotting the AUC from 0 to infinity. Examples -------- . ^auccalc time conc^ (Show measures) . ^auccalc time conc, fit(7)^ (Use last 7 point to fit model) . ^auccalc time conc, t^ (Use trapazodial rule in calculating AUC)