.- help for ^phenotyp^ (STB-61: dm92) .- Simulating disease status and censored age ------------------------------------------ ^phenotyp^ hr [^, t^ype^(d^ | ^r) a^lpha^(^#^) l^ambda^(^#^) m^axage^(^#^)^ ^g^amma^(^#^) s^ex^(b^ | ^f^ | ^m)^] Description ----------- ^phenotyp^ is a command used to generate the disease status and censored age of individuals in simulated families on the basis of age, sex, and genotype that are generated by ^simuped2^ or ^simuped3^ previously (Cui 2000). An censored age is the age at onset of a disease if a person is affected, or the age of death if a person has died before developing the disease. Otherwise it is the calendar age simulated by ^simuped2^ or ^simuped3^. ^phenotyp^ expects the genetic hazard ratio, hr, to be specified as a non-negative value following this command. Options ------- ^type(^inheritance^)^ specifies the type of inheritance. ^d^ (the default) specifies dominant inheritance, and ^r^ specifies recessive inheritance. ^alpha(^#^)^ specifies the shape parameter of the Weibull distribution. The default value is 4.21. ^lambda(^#^)^ specifies the scale parameter of the Weibull distribution. The default value is 9.95e-10. ^maxage(^#^)^ specifies the upper bound of age of death. The default value is 100. ^gamma(^#^)^ specifies the parameter in the log-power density function of death. The default value is 15. ^sex(^text^)^ specifies the sex affected by a disease. ^b^ (the default) specifies that both sexes are affected, ^f^ specifies that female only affected, and ^m^ specifies that males are only affected by the disease. Examples -------- . ^simuped2 70 10 40 10, reps(1000) sav(output) alle(0.05) sib(5)^ . ^use output^ . ^phenotyp 10, type(d) alpha(4.21) lambda(9.95e-10) maxage(100) gamma(15) s(f)^ Author ------ Jisheng Cui University of Melbourne j.cui@@unimelb.edu.au