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From |
Michael McCulloch <mm@pinestreetfoundation.org> |

To |
statalist@hsphsun2.harvard.edu |

Subject |
Re: st: metan question, |

Date |
Fri, 10 Sep 2010 09:15:11 -0700 |

Thank you Tiago, this is very helpful. Michael On Sep 8, 2010, at 10:47 PM, Tiago V. Pereira wrote:

Michael, I believe you need further information on the data you have at hand: either the t statistic or a correly reported P-value, say, P = 0.052. Once you have one of these pieces of information, you can compute anapproximated value for the variance for your effect size (thedifferencebetween "after" and "before"). See the formulations in classic statistical books.Denote the effect size as ES, the standard deviation as SD and thesamplesize as N.So, you end up with an N1, ES1 and SD1 for group 1 and N2, ES2 andSD2 forgroup 2, the exact information required by -metan-.If you don't have these information, I believe you have twostrategies:Assuming you have the following data for group 1: N1 = number of subjects (identical in the "before" and "after") m1 = mean before intervention m2 = mean after intervention sd1 = standard deviation before intervention sd2 = standard deviation after intervention You can compute the effect size "after vs before" as: ES1 = m2-m1 And an approximate standard deviation for ES1:SD1 = sqrt(((sd1^2)/(N1))+((sd2^2)/(N1))-(2*sd1*sd2*rho)/N1)*(sqrt(N1))where rho is the correlation between observations from m2 and m1.However, one does not know the correlation from summary data.hence, yourtwo strategies are:(1) set rho = 0, and ignore the correlation. This reduces the powerof themeta-analysis when rho>0.(2) set several values of rho and check how results change. thesevaluescan be obtained from some studies that you have raw data, or from literature. Let me know if that works for you. Cheers! Tiago ---------------------------------------- Michael wrote: ello, I notice that -metan- requires the following for continuous data: sample size, mean difference, and standard deviation (SD) of the experimental group followed by those of the control group. Thiscould be used, for example, to pool data such as mean difference inbloodpressure before and after an intervention. However, if instead of the sample size, mean difference and standard deviation, I had for both groups: sample size, mean blood pressure before intervention standard deviation (SD) sample size, mean blood pressure after intervention standard deviation (SD) would it be possible to convert into the format required by -metan-? Best wishes, Michael McCulloch, LAc MPH PhD Pine Street Foundation 124 Pine Street San Anselmo, CA 94960-2674 tel: 415-407-1357 fax: 206-338-2391 * * For searches and help try: * http://www.stata.com/help.cgi?search * http://www.stata.com/support/statalist/faq * http://www.ats.ucla.edu/stat/stata/

Best wishes, Michael McCulloch, LAc MPH PhD Pine Street Foundation 124 Pine Street San Anselmo, CA 94960-2674 tel: 415-407-1357 fax: 206-338-2391 * * For searches and help try: * http://www.stata.com/help.cgi?search * http://www.stata.com/support/statalist/faq * http://www.ats.ucla.edu/stat/stata/

**References**:**RE: st: metan question,***From:*"Tiago V. Pereira" <tiago.pereira@mbe.bio.br>

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