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st: Testing dependence in a 2x2 table for clustered observations

From   "Hoogendoorn, Adriaan" <>
To   "" <>
Subject   st: Testing dependence in a 2x2 table for clustered observations
Date   Wed, 25 Aug 2010 09:59:52 +0200

Dear Statalisters,

I have a very simple 2x2 table Treatment (A or B) versus Recovered (Yes or No).. I would like to test the dependence in the table using a chi square test. However, the observations are not independent but clustered: a multilevel design with patients clustered in approximately twenty "treatment sites".

My question is, in order to take the clustering into account, do I need to use a technique like random coefficient logistic regression? This seems like heavy machinery to solve a simple problem with only a minor complication?

Kind regards,
Adriaan Hoogendoorn
GGZ inGeest, Amsterdam

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