Re: st: pk analysis suite: elementary questions about -pkequiv-, -pkcross-, and -pkshape-

[Michael McCulloch <mm@pinestreetfoundation.org>]

Thank you Joseph, I've ordered a copy of Stephen Senn's text, and  
wasn't dismayed by the title of Pippa M. Simpson's poster. Looks like  
both will be useful learning tools, and I appreciate your having  
recommended them.
Michael


On Feb 20, 2010, at 8:27 PM, Joseph Coveney wrote:

> Michael McCulloch wrote:
>
> Thank you kindly for the very helpful response and example.
> You write "the potential for carryover effects (by whatever name) to
> confound crossover studies
> is often more serious with outcomes other than chemical
> concentrations." Might you be able to recommend some reading (either
> published or online tutorials) on this issue in crossover studies?
>
> --------------------------------------------------------------------------------
>
> Outside of the biopharmaceutics-specific literature, the following  
> reference
> would be a good place to start:
>
> Stephen J. Senn, _Cross-over Trials in Clinical Research_  Second  
> Edition.
> Chichester: John Wiley & Sons, 2002.
>
>
> Online, there is a paper delivered at a SAS meeting some years ago:
>
> http://www2.sas.com/proceedings/sugi24/Posters/p221-24.pdf
>
> Its title comes across as a bit too negative, but the paper does  
> touch on some
> of the pitfalls in design and execution of a crossover study.
>
> Joseph Coveney
>
>
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Best wishes,

Michael McCulloch
Pine Street Foundation
124 Pine Street
San Anselmo, CA 94960-2674
tel:	415-407-1357
fax: 	206-338-2391

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