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Re: st: R: Extrapolated inferences and confidence intervals


From   Fred Wolfe <fwolfe@arthritis-research.org>
To   statalist@hsphsun2.harvard.edu
Subject   Re: st: R: Extrapolated inferences and confidence intervals
Date   Thu, 25 Jun 2009 05:20:00 -0500

Thanks Carlo, Maarten, and Stas,

I'll try the analyses with the suggested methods.

Fred

On Wed, Jun 24, 2009 at 11:16 AM, Carlo Lazzaro
<carlo.lazzaro@tiscalinet.it> wrote:
>
> Dear Fred,
> Scanning Little RJA, Rubin DB. Statistical analysis with missing data.
> Second edition. Chichester: Wiley, 2002, I have found out one chapter only
> covering dichotomous data (pages 266-291): The reported examples are not
> related to epidemiology and are dealth with using Bayesian or ML approaches.
>
> This is probably a trivial solution to your problem: assuming you are
> dealing with MCAR mechanism, can't you simply bootstrap the existing
> observation and calculate the prevalence 95% CI?
>
> Kind Regards,
> Carlo
>
> -----Messaggio originale-----
> Da: owner-statalist@hsphsun2.harvard.edu
> [mailto:owner-statalist@hsphsun2.harvard.edu] Per conto di Fred Wolfe
> Inviato: mercoledì 24 giugno 2009 16.52
> A: statalist@hsphsun2.harvard.edu
> Oggetto: st: Extrapolated inferences and confidence intervals
>
> I wonder if anyone on the Stata list may be able to suggest a method
> to solve this problem using Stata.
>
> I am trying do determine the prevalence and confidence intervals of a
> side effect to a treatment. Several thousand treated subjects have
> taken a drug. They are asked if they had a specific side effect to the
> drug. Those that say no are classified as being side effect negative.
> Those that say yes are contacted to obtain the name of their
> physician, and the physician is asked to verify the side effect. Only
> about one third of physicians can be contacted, and from them we can
> get the proportion positive and negative for the side effect. Assume
> that the non-responses are unrelated to the outcome. I can extrapolate
> from the responding physicians to the non-responding physicians and
> calculate an overall prevalence of the side effect. What I would like
> to do is to obtain confidence intervals for this prevalence estimate,
> but I do not see an easy way to do this in Stata. I wonder if anyone
> might suggest a solution.
>
> Thanks,
>
> Fred
>
> --
> Fred Wolfe
> National Data Bank for Rheumatic Diseases
> Wichita, Kansas
> NDB Office  +1 316 263 2125 Ext 0
> Research Office +1 316 686 9195
> fwolfe@arthritis-research.org
>
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--
Fred Wolfe
National Data Bank for Rheumatic Diseases
Wichita, Kansas
NDB Office  +1 316 263 2125 Ext 0
Research Office +1 316 686 9195
fwolfe@arthritis-research.org

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