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st: Informative censoring in a dental pain study


From   "Boye, Mark" <mark.boye@pfizer.com>
To   "'statalist@hsphsun2.harvard.edu'" <statalist@hsphsun2.harvard.edu>
Subject   st: Informative censoring in a dental pain study
Date   Tue, 8 Feb 2005 17:11:25 -0500

I am seeking to analyze  time from tooth extraction to time to a 30%
reduction in pain with 4 active treatment arms and a placebo control in a 24
hr randomized, double-blind clinical trial.  The dilemma is that after 1
hour, patients in sufficient pain are permitted to drop out of the study and
take rescue medication.  Hence, this appears to be a case of informative
censoring.

Can list members suggest how to estimate an appropriate model in STATA (or
SAS)?

Thank you,
Mark


Mark E. Boye MBA, MPH, Ph.D.
Sr. Outcomes Research Scientist
WW Outcomes Research
Midwest/Ann Arbor Development Site
Pfizer Inc
1600/300/327
2800 Plymouth Road
Ann Arbor, MI  48015-2430
Tel: 734-622-4856
Fax: 734-622-2641
E-mail: mark.boye@pfizer.com




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