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st: Meta-analysis of SMRs


From   "Fenty, J." <jf48@leicester.ac.uk>
To   "Statalist (E-mail)" <statalist@hsphsun2.harvard.edu>
Subject   st: Meta-analysis of SMRs
Date   Wed, 1 Sep 2004 12:41:45 +0100

Dear statlist

I am conducting meta-analyses of SMRs using the -meta- command which works fine until you have observed values of zero. I am using the formulae

			log(SMR) = log(observed/expected)
			se(log(SMR)) = 1/sqrt(observed)

and both are undefined when the observed value=0. Does anyone have any suggestions for dealing with this situation other than
omitting studies with zeroes or combining them with other studies? Are there other formulae to calculate se(log(SMR)) which is not based solely on the observed value?

Many thanks,

Justin Fenty

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