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RE: st: cox proportional hazard and correlated data


From   "Fischer, Marcus" <[email protected]>
To   <[email protected]>
Subject   RE: st: cox proportional hazard and correlated data
Date   Tue, 11 May 2004 14:41:27 -0500

Thank you Ricardo. This sounds reasonable to me.

Cheers,
Marcus

 -----Original Message-----
From: 	[email protected] [mailto:[email protected]]  On Behalf Of Ricardo Ovaldia
Sent:	Tuesday, May 11, 2004 2:03 PM
To:	[email protected]
Subject:	Re: st: cox proportional hazard and correlated data

I believe that the standard approach is to use a share
frailty model. This can be done using -stcox-'s
-share()- option.

Best,
Ricardo.

--- "Fischer, Marcus" <[email protected]> wrote:
> Hi,
> 
> I wish to evaluate associations between prospective
> disease risk and one or more genetic or
> environmental covariates, using data from families
> ascertained because of the disease statuses of some
> of their members. The population consists of
> nonoverlapping families each containing one or more
> individuals. Both disease occurences and covariates
> may be correlated within families.
> Is it possible to account for the within-family
> correlation in a cox proportional hazard model ? If
> so, how ?
> Can I just use the cluster(family-identifier) option
> to work with the robust variance-covariance matrix ?
> 
> Thanks for your help.
> Marcus
> 
> 
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