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st: RE: more cases than controls


From   Laurel.Copeland@med.va.gov
To   statalist@hsphsun2.harvard.edu
Subject   st: RE: more cases than controls
Date   Tue, 23 Mar 2004 08:43:08 -0500

It is possible the reviewer read the ms too hastily. I'd advise
diplomatically explaining (in the letter not the paper) that the study was a
case-control study but not a matched case-control study, and that you have
revised the ms to make the study design clearer.  Good luck!

-----Original Message-----
From: Ricardo Ovaldia [mailto:ovaldia@yahoo.com]
Sent: Monday, March 22, 2004 3:57 PM
To: statalist@hsphsun2.harvard.edu
Subject: st: more cases than controls

Dear all,

Please pardon the non-Stata topic.

We recently submitted a manuscript for publication to
a major medical journal. It was a case-control study
with 329 cases and 126 controls. One of the reviewers
wrote that "to have such a larger number of cases was
statistically atypical" and asked if the "authors find
that the use of the same control for multiple patients
significantly limits results"?

I never heard of any biases or other problems cause by
having more cases than controls in a study. We had
sufficient power and the difference for our main
outcome was highly significant (less than 0.00001). Am
I missing something or is it that this reviewer does
not understand the case-control designed? By the way
this was not a matched study design.
 
Thank you,
Ricardo.
 

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