Stata The Stata listserver
[Date Prev][Date Next][Thread Prev][Thread Next][Date index][Thread index]

st: RE: more cases than controls

Subject   st: RE: more cases than controls
Date   Tue, 23 Mar 2004 08:43:08 -0500

It is possible the reviewer read the ms too hastily. I'd advise
diplomatically explaining (in the letter not the paper) that the study was a
case-control study but not a matched case-control study, and that you have
revised the ms to make the study design clearer.  Good luck!

-----Original Message-----
From: Ricardo Ovaldia []
Sent: Monday, March 22, 2004 3:57 PM
Subject: st: more cases than controls

Dear all,

Please pardon the non-Stata topic.

We recently submitted a manuscript for publication to
a major medical journal. It was a case-control study
with 329 cases and 126 controls. One of the reviewers
wrote that "to have such a larger number of cases was
statistically atypical" and asked if the "authors find
that the use of the same control for multiple patients
significantly limits results"?

I never heard of any biases or other problems cause by
having more cases than controls in a study. We had
sufficient power and the difference for our main
outcome was highly significant (less than 0.00001). Am
I missing something or is it that this reviewer does
not understand the case-control designed? By the way
this was not a matched study design.
Thank you,

Do you Yahoo!?
Yahoo! Finance Tax Center - File online. File on time.
*   For searches and help try:
*   For searches and help try:

© Copyright 1996–2017 StataCorp LLC   |   Terms of use   |   Privacy   |   Contact us   |   What's new   |   Site index