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Re: st: Haplotype Estimation


From   <Adrian.P.Mander@gsk.com>
To   statalist@hsphsun2.harvard.edu
Subject   Re: st: Haplotype Estimation
Date   Thu, 21 Aug 2003 15:10:38 +0100

I never calculate the score function within -qhapipf-

But then you can do any likelihood ratio test comparing the trait and the
haplotypes..

Or are you looking to estimate a "wald" type test of an individual
haplotype and the trait? This
is something that can possibly coax out the answer to.

cheers
Ade


                                                                                                                               
                    "Andrea Baccarelli"                                                                                        
                    <andreastata5@hotmail.com>                                                                                 
                                                                                                                               
                    Sent by:                         To:     statalist@hsphsun2.harvard.edu                                    
                    owner-statalist@hsphsun2.h                                                                                 
                    arvard.edu                       cc:                                                                       
                                                     Subject:     st: Haplotype Estimation                                     
                                                                                                                               
                    19-Aug-2003 01:25                                                                                          
                    Please respond to                                                                                          
                    statalist@hsphsun2.harvard                                                                                 
                    .edu                                                                                                       
                                                                                                                               
                                                                                                                               



Two questions related to the estimation of haplotypes from genotype data
from phase uncertainty:

1. Schaid (Am J Hum Gen 2002) proposed the use of the score test for
assessing the association between haplotype data estimated using the
EM-algorithm and any given trait assessed in the same subject. Does Stata
allow to perform a Score test?

2. Is there any way to perform the such Score test using the command
qhapipf?

Thanks,
Andrea

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