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Re: st: one/two-site competitive binding ado


From   Joseph Coveney <jcoveney@bigplanet.com>
To   Statalist <statalist@hsphsun2.harvard.edu>
Subject   Re: st: one/two-site competitive binding ado
Date   Thu, 17 Apr 2003 06:39:55 +0900

David Airey asked, "Has anyone ado files to perform nl regression models for one and 
two site competitive binding assays? There are several other pharmacological assays in 
GraphPad Prism 3.0 that I wondered if anyone has duplicated in Stata?"

In the first volume of Stata Technical Bulletin Reprints, pp. 68-73 and continuing pp. 73-
76, Paul Geiger provided descriptions of using Stata for radioimmunoassay ligand-
binding analysis.  This would be one-site binding. The program he used was an early 
version of a nonlinear least-squares regression ado-file in Stata, but an analogous setup 
using the current -nl- ought to be straightforward.

If you have the nonlinear function written out for two-site binding, then it ought to be 
fairly easy to implement in Stata using -nl- or even -ml-.  The latter has advantages in a 
-cluster()- option; see the FAQ by Weihua Guan at 
www.stata.com/support/faqs/stat/nl_ml.html .

I'm not sure what GraphPad Prism 3.0 has for the other pharmacological assays.  In 
general, if the functions are available, then setting up the proper ado-file to be called by 
-nl- will be feasible.

Joseph Coveney




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