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Biostatistics

Biostatisticians rely on Stata because of its breadth, accuracy, extensibility, and reproducibility. Regardless of your focus area—public health, cancer, HIV, clinical observational studies, clinical trials—or your statistical approach, whether cross-sectional, longitudinal, or time-to-event, Stata provides all the statistics, graphics, and data management tools needed to implement and study a wide range of biostatistical methods.



Features for biostatisticians

Survival analysis
Analyze duration outcomes—outcomes measuring the time to an event such as failure or death—using Stata's specialized tools for survival analysis. Account for the complications inherent in survival data, such as sometimes not observing the event (right-, left-, and interval-censoring), individuals entering the study at differing times (delayed entry), and individuals who are not continuously observed throughout the study (gaps). You can estimate and plot the probability of survival over time. Or model survival as a function of covariates using Cox, Weibull, lognormal, and other regression models. Predict hazard ratios, mean survival time, and survival probabilities. Do you have groups of individuals in your study? Adjust for within-group correlation with a random-effects or shared-frailty model. If you have many potential covariates, use lasso cox and elasticnet cox for model selection and prediction.

Multilevel mixed-effects models
Whether the groupings in your data arise in a nested fashion (patients nested in clinics and clinics nested in regions) or in a nonnested fashion (regions crossed with occupations), you can fit a multilevel model to account for the lack of independence within these groups. Fit models for continuous, binary, count, ordinal, and survival outcomes. Estimate variances of random intercepts and random coefficients. Compute intraclass correlations. Predict random effects. Estimate relationships that are population averaged over the random effects.

Bayesian analysis
Fit Bayesian regression models using one of the Markov chain Monte Carlo (MCMC) methods. You can choose from various supported models or even program your own. Extensive tools are available to check convergence, including multiple chains. Compute posterior mean estimates and credible intervals for model parameters and functions of model parameters. You can perform both interval- and model-based hypothesis testing. Compare models using Bayes factors. Compute model fit using posterior predictive values and generate predictions. If you want to account for model uncertainty in your regression model, use Bayesian model averaging.

Power, precision, and sample size
Before you conduct your experiment, determine the sample size needed to detect meaningful effects without wasting resources. Do you intend to compute CIs for means or variances or perform tests for proportions or correlations? Do you plan to fit a Cox proportional hazards model or compare survivor functions using a log-rank test? Do you want to use a Cochran—Mantel—Haenszel test of association or a Cochran—Armitage trend test? Use Stata's power command to compute power and sample size, create customized tables, and automatically graph the relationships between power, sample size, and effect size for your planned study. Or use the ciwidth command to do the same but for CIs instead of hypothesis tests by computing the required sample size for the desired CI precision. Or use gsdesign to compute stopping boundaries and the required sample sizes for group sequential designs. Instead of commands, use the interactive Control Panel to perform your analysis.

Linear, binary, and count regressions
Fit classical ANOVA and linear regression models of the relationship between a continuous outcome, such as weight, and the determinants of weight, such as height, diet, and level of exercise. If your response is binary, ordinal, categorical, or count, don't worry. Stata has estimators for these types of outcomes too. Use logistic regression to estimate odds ratios. Estimate incidence rates using a Poisson model. Analyze matched case–control data with conditional logistic regression. A vast array of tools is available after fitting such models. Predict outcomes and their confidence intervals. Test equality of parameters. Compute linear and nonlinear combinations of parameters.

Meta-analysis
Combine results of multiple studies to estimate an overall effect. Use forest plots to visualize results. Use subgroup analysis and meta-regression to explore study heterogeneity. Use funnel plots and formal tests to explore publication bias and small-study effects. Use trim-and-fill analysis to assess the impact of publication bias on results. Perform cumulative and leave-one-out meta-analysis. Perform univariate, multilevel, and multivariate meta-analysis. Use the meta suite, or let the Control Panel interface guide you through your entire meta-analysis.

Multiple imputation
Account for missing data in your sample using multiple imputation. Choose from univariate and multivariate methods to impute missing values in continuous, censored, truncated, binary, ordinal, categorical, and count variables. Then, in a single step, estimate parameters using the imputed datasets, and combine results. Fit a linear model, logit model, Poisson model, hierarchical model, survival model, or one of the many other supported models. Use the mi command, or let the Control Panel interface guide you through your entire MI analysis.

Marginal means, contrasts, and interactions
Marginal means and contrasts let you analyze the relationships between your outcome variable and your covariates, even when that outcome is binary, count, ordinal, categorical, or survival. Compute adjusted predictions with covariates set to interesting or representative values. Or compute marginal means for each level of a categorical covariate. Make comparisons of the adjusted predictions or marginal means using contrasts. If you have multilevel data and random effects, these effects are automatically integrated out to provide marginal (that is, population-averaged) estimates. After fitting almost any model in Stata, analyze the effect of covariate interactions, and easily create plots to visualize those interactions.

Causal inference
Estimate experimental-style causal effects from observational data. With Stata's treatment-effects estimators, you can use a potential-outcomes (counterfactuals) framework to estimate, for instance, the effect of family structure on child development or the effect of unemployment on anxiety. Fit models for continuous, binary, count, fractional, and survival outcomes with binary or multivalued treatments using inverse-probability weighting (IPW), propensity-score matching, nearest-neighbor matching, regression adjustment, or doubly robust estimators. If the assignment to a treatment is not independent of the outcome, you can use an endogenous treatment-effects estimator. In the presence of group and time effects, you can use difference-in-differences (DID) and triple-differences (DDD) estimators. In the presence of high-dimensional covariates, you can use lasso. If causal effects are mediated through another variable, use causal mediation with mediate to disentangle direct and indirect effects.

Epidemiological tables
Want to analyze data from a prospective (incidence) study, cohort study, case–control study, or matched case–control study? Stata's tables for epidemiologists make it easy to summarize your data and compute statistics such as incidence-rate ratios, incidence-rate differences, risk ratios, risk differences, odds ratios, and attributable fractions. You can analyze stratified data too—compute Mantel–Haenszel combined estimates, perform tests of homogeneity, and standardize estimates. If you have an ordinal rather than binary exposure, you can perform a test for a trend.

Programming
Want to program your own commands to perform estimation, perform data management, or implement other new features? Stata is programmable, and thousands of Stata users have implemented and published thousands of community-contributed commands. These commands look and act just like official Stata commands and are easily installed for free over the Internet from within Stata. A unique feature of Stata's programming environment is Mata, a fast and compiled language with support for matrix types. Of course, it has all the advanced matrix operations you need. It also has access to the power of LAPACK. What's more, it has built-in solvers and optimizers to make implementing your own maximum likelihood, GMM, or other estimators easier. And you can leverage all of Stata's estimation and other features from within Mata. Many of Stata's official commands are themselves implemented in Mata.

PyStata—Python integration
Interact Stata code with Python code. You can seamlessly pass data and results between Stata and Python. You can use Stata within Jupyter Notebook and other IPython environments. You can call Python libraries such as NumPy, matplotlib, Scrapy, scikit-learn, and more from Stata. You can use Stata analyses from within Python.

Survey methods
Whether your data require a simple weighted adjustment because of differential sampling rates or you have data from a complex multistage survey, Stata's survey features can provide you with correct standard errors and confidence intervals for your inferences. Simply specify the relevant characteristics of your sampling design, such as sampling weights (including weights at multiple stages), clustering (at one, two, or more stages), stratification, and poststratification. After that, most of Stata's estimation commands can adjust their estimates to correct for your sampling design.

Automated reporting and customizable tables
Stata is designed for reproducible research, including the ability to create dynamic documents incorporating your analysis results. Create Word or PDF files, populate Excel worksheets with results and format them to your liking, and mix Markdown, HTML, Stata results, and Stata graphs, all from within Stata. Create tables that compare regression results or summary statistics, use default styles or apply your own, and export your tables to Word, PDF, HTML, LaTeX, Excel, or Markdown and include them in your reports.

As a biostatistician with responsibility for dealing with daily inquiries from the medical and dental schools in my university, I find that Stata provides the broadest statistical base for data analysis.

— Alan Kelly
Department Community Health & General Practice, Trinity College, Dublin, Ireland

Check out Stata's full list of features, or see what's new in Stata 18.

Why Stata?

Intuitive and easy to use.
Once you learn the syntax of one estimator, graphics command, or data management tool, you will effortlessly understand the rest.

Accuracy and reliability.
Stata is extensively and continually tested. Stata's tests produce approximately 5.8 million lines of output. Each of those lines is compared against known-to-be-accurate results across editions of Stata and every operating system Stata supports to ensure accuracy and reproducibility.

One package. No modules.
When you buy Stata, you obtain everything for your statistical, graphical, and data analysis needs. You do not need to buy separate modules or import your data to specialized software.

Write your own Stata programs.
You can easily write your own Stata programs and commands. Share them with others or use them to simplify your work. Utilize Stata's do-files, ado-files, and Mata: Stata's own advanced programming language that adds direct support for matrix programming. You can also access and benefit from the thousands of existing Stata community-contributed programs.

Extensive documentation.
Stata offers 35 manuals with more than 18,000 pages of PDF documentation containing detailed examples, in-depth discussions, references to relevant literature, and methods and formulas. Stata's documentation is a great place to learn about Stata and the statistics, graphics, data management, and data science tools you are using for your research.

Top-notch technical support.
Stata's technical support is known for their prompt, accurate, detailed, and clear responses. People answering your questions have master's and PhD degrees in relevant areas of research.

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For Stata users, by Stata users

Stata Press offers books with clear, step-by-step examples that make teaching easier and that enable students to learn and biostatisicians to implement the latest best practices in analysis.


Alan C. Acock

Mario Cleves, William W. Gould, and Yulia V. Marchenko

Nicholas J. Cox

Ulrich Kohler and Frauke Kreuter

J. Scott Long and Jeremy Freese

Michael N. Mitchell

Michael N. Mitchell

Michael N. Mitchell

Sophia Rabe-Hesketh and Anders Skrondal

Tom M. Palmer and Jonathan A. C. Sterne (editors)